Etodolac + Methotrexate Interaction
Majorinteraction on record
Description
Etodolac may cause elevated serum levels and increased toxicity of methotrexate. Should not be administered prior to or concomitantly with high-dose methotrexate.
Mechanism
Competitive inhibition of methotrexate accumulation and effects on renal prostaglandins
Source: NLP:etodolac