Esomeprazole Magnesium + Methotrexate Interaction
Majorinteraction on record
Description
Concomitant use may elevate and prolong serum concentrations of methotrexate and metabolite hydroxymethotrexate, possibly leading to methotrexate toxicities.
Mechanism
PPI impairs methotrexate clearance
Source: NLP:esomeprazole magnesium