Ertapenem + Divalproex Sodium Interaction
Majorinteraction on record
Description
Ertapenem reduces divalproex sodium concentrations below therapeutic range, increasing risk of breakthrough seizures. Concomitant use is generally not recommended.
Mechanism
Carbapenems may inhibit hydrolysis of valproic acid's glucuronide metabolite back to valproic acid
Source: NLP:ertapenem