Empagliflozin Linagliptin Metformin Hydrochloride + Cimetidine Interaction
Majorinteraction on record
Description
OCT2/MATE inhibitor that interferes with renal elimination of metformin, increasing systemic exposure and risk of lactic acidosis.
Mechanism
Inhibition of organic cationic transporter-2 (OCT2) and multidrug and toxin extrusion (MATE) transporters
Source: NLP:empagliflozin, linagliptin, metformin hydrochloride