Empagliflozin And Metformin Hydrochloride + Cimetidine Interaction

Majorinteraction on record

Description

Cimetidine inhibits metformin clearance via OCT2/MATE, increasing metformin exposure and risk of lactic acidosis.

Mechanism

Interferes with renal tubular transport systems (OCT2/MATE inhibitor) involved in metformin elimination

Source: NLP:empagliflozin and metformin hydrochloride