Elexacaftor Tezacaftor And Ivacaftor + Ketoconazole Interaction
Majorinteraction on record
Description
Strong CYP3A inhibitor increases ivacaftor AUC 8.5-fold and significantly increases elexacaftor and tezacaftor exposures. TRIKAFTA dosage reduction required.
Mechanism
CYP3A inhibition
Source: NLP:elexacaftor, tezacaftor, and ivacaftor