Elexacaftor Tezacaftor And Ivacaftor + Itraconazole Interaction
Majorinteraction on record
Description
Strong CYP3A inhibitor increases elexacaftor AUC 2.8-fold and tezacaftor AUC 4.0-4.5-fold, ivacaftor AUC 15.6-fold. TRIKAFTA dosage reduction required.
Mechanism
CYP3A inhibition
Source: NLP:elexacaftor, tezacaftor, and ivacaftor