Efavirenz + Valoctocogene Roxaparvovec Rvox Interaction
Majorinteraction on record
Description
One HIV-positive patient experienced asymptomatic elevations of ALT, AST, GGT (>5.0 × ULN) and serum bilirubin (>ULN to 1.5 × ULN) at Week 4. Reaction resolved after changing antiretroviral regimen to exclude efavirenz.
Mechanism
Efavirenz suppresses factor VIII transcription independent of hepatotoxicity
Source: NLP:valoctocogene roxaparvovec-rvox