Dolutegravir Sodium And Rilpivirine Hydrochloride + Metformin Interaction

Moderateinteraction on record

Description

Dolutegravir inhibits OCT2 and MATE1, potentially increasing metformin plasma concentrations. Monitor renal function and metformin levels.

Mechanism

Inhibition of renal organic cation transporter 2 (OCT2) and multidrug and toxin extrusion transporter 1 (MATE1)

Source: NLP:dolutegravir sodium and rilpivirine hydrochloride