Dolutegravir Sodium And Rilpivirine Hydrochloride + Dalfampridine Interaction
Contraindicatedinteraction on record
Description
Dolutegravir inhibits OCT2 and MATE1, increasing dalfampridine plasma concentrations. Consider alternatives due to risk of Torsade de Pointes.
Mechanism
Inhibition of renal organic cation transporter 2 (OCT2) and multidrug and toxin extrusion transporter 1 (MATE1)
Source: NLP:dolutegravir sodium and rilpivirine hydrochloride