Dolutegravir Sodium + Etravirine Interaction

Majorinteraction on record

Description

Etravirine significantly reduces plasma concentrations of dolutegravir, reducing therapeutic effect; coadministration with lopinavir/ritonavir, darunavir/ritonavir, or atazanavir/ritonavir may mitigate this effect.

Mechanism

Enzyme induction reducing dolutegravir exposure

Source: NLP:dolutegravir sodium