Dolutegravir Sodium + Dofetilide Interaction
Majorinteraction on record
Description
Dolutegravir may increase plasma concentrations of dofetilide via OCT2 or MATE1 inhibition, potentially leading to serious adverse effects.
Mechanism
Inhibition of renal organic cation transporter OCT2 and MATE1
Source: NLP:dolutegravir sodium