Dofetilide + Lamotrigine Extended Release Interaction
Contraindicatedinteraction on record
Description
Coadministration with lamotrigine ER is not recommended due to narrow therapeutic index and increased plasma levels via OCT2 inhibition.
Mechanism
Inhibition of organic cationic transporter 2 (OCT2)-mediated renal tubular secretion
Source: NLP:lamotrigine er