Digoxin + Indomethacin Interaction
Majorinteraction on record
Description
Indomethacin may prolong digoxin half-life, increasing risk of digoxin toxicity. Close monitoring with frequent ECGs and serum digoxin levels required in neonates.
Mechanism
Prolongation of digoxin half-life when given concomitantly with indomethacin
Source: NLP:indomethacin