Dexrazoxane + Doxorubicin Hydrochloride Interaction
Contraindicatedinteraction on record
Description
Do not administer dexrazoxane as a cardioprotectant at the initiation of doxorubicin hydrochloride-containing chemotherapy. Initiation with doxorubicin resulted in significantly lower tumor response rate (48% vs. 63%) and shorter time to progression.
Mechanism
Decreased tumor response rate and shorter time to progression
Source: NLP:doxorubicin hydrochloride