Desipramine Hydrochloride + Fluoxetine Interaction
Majorinteraction on record
Description
SSRI inhibitor of P450 2D6 that may increase desipramine plasma concentrations. At least 5 weeks required before initiating desipramine after fluoxetine withdrawal due to long half-life.
Mechanism
CYP2D6 inhibition
Source: NLP:desipramine hydrochloride