Dapagliflozin And Metformin Hydrochloride + Topiramate Interaction

Majorinteraction on record

Description

Decreases serum bicarbonate and induces metabolic acidosis; concomitant use may increase risk for lactic acidosis.

Mechanism

Carbonic anhydrase inhibition causing non-anion gap, hyperchloremic metabolic acidosis

Source: NLP:dapagliflozin and metformin hydrochloride