Cyp3a Inducers + Osimertinib Interaction

Majorinteraction on record

Description

Co-administration decreases osimertinib exposure, potentially reducing efficacy. Avoid concomitant use or increase osimertinib dose to 160 mg daily if unavoidable.

Mechanism

CYP3A4-mediated induction decreases osimertinib exposure

Source: NLP:osimertinib