Cyp3a Inducers + Olanzapine And Samidorphan L Malate Interaction
Majorinteraction on record
Description
Coadministration decreases AUC and Cmax of olanzapine and samidorphan, which may reduce LYBALVI efficacy. Concomitant use is not recommended.
Mechanism
CYP3A4-mediated induction decreasing drug exposure
Source: NLP:olanzapine and samidorphan l-malate