Cyp3a Inducers + Olanzapine And Samidorphan L Malate Interaction

Majorinteraction on record

Description

Coadministration decreases AUC and Cmax of olanzapine and samidorphan, which may reduce LYBALVI efficacy. Concomitant use is not recommended.

Mechanism

CYP3A4-mediated induction decreasing drug exposure

Source: NLP:olanzapine and samidorphan l-malate