Cyp3a Inducers + Darunavir Cobicistat Emtricitabine And Tenofovir Alafenamide Interaction

Moderateinteraction on record

Description

Co-administration may increase clearance of darunavir and cobicistat, resulting in lowered plasma concentrations and potential loss of therapeutic effect and development of resistance.

Mechanism

Increased metabolism of darunavir and cobicistat by CYP3A

Source: NLP:darunavir, cobicistat, emtricitabine, and tenofovir alafenamide