Cyclosporine + Rapamycin Interaction
Majorinteraction on record
Description
Cyclosporine increases sirolimus concentrations. Sirolimus should be taken 4 hours after cyclosporine administration. Dose adjustment may be needed if cyclosporine is withdrawn.
Mechanism
Cyclosporine is a substrate and inhibitor of CYP3A4 and P-gp
Source: NLP:sirolimus