Cyclophosphamide Injection Solution + Protease Inhibitors Interaction
Majorinteraction on record
Description
Protease inhibitors may increase concentration of cyclophosphamide cytotoxic metabolites, associated with higher incidence of infections and neutropenia.
Mechanism
Inhibition of cytochrome P450-mediated activation of cyclophosphamide pro-drug
Source: NLP:cyclophosphamide injection, solution