Colesevelam Hydrochloride + Norethindrone Interaction
Majorinteraction on record
Description
Colesevelam may decrease norethindrone exposure when coadministered with oral contraceptives. In vivo studies demonstrated decreased exposure. Administer 4 hours prior to colesevelam.
Mechanism
Bile acid sequestrant binding reducing drug absorption
Source: NLP:colesevelam hydrochloride