Codeine Phosphate And Chlorpheniramine Maleate + Rifampin Interaction

Majorinteraction on record

Description

CYP3A4 inducer can result in lower codeine and morphine levels, decreasing efficacy or causing withdrawal syndrome. Avoid concomitant use.

Mechanism

Induction of CYP3A4 decreases codeine metabolism to morphine via CYP2D6

Source: NLP:codeine phosphate and chlorpheniramine maleate