Cocaine Hydrochloride + Disulfiram Interaction
Majorinteraction on record
Description
Increases plasma cocaine exposure (AUC and Cmax) by several fold after intranasal or intravenous administration. Avoid use of cocaine hydrochloride nasal solution in patients taking disulfiram.
Mechanism
Disulfiram increases plasma cocaine exposure through unknown mechanism
Source: NLP:cocaine hydrochloride