Cobimetinib + Rifampin Interaction
Majorinteraction on record
Description
Strong CYP3A inducer may decrease cobimetinib exposure by >80% and reduce efficacy. Avoid concurrent use.
Mechanism
CYP3A induction
Source: NLP:cobimetinib
Strong CYP3A inducer may decrease cobimetinib exposure by >80% and reduce efficacy. Avoid concurrent use.
CYP3A induction
Source: NLP:cobimetinib