Clonidine + Metoprolol Interaction
Majorinteraction on record
Description
Increases bradycardia risk; beta-blockers may exacerbate rebound hypertension following clonidine withdrawal. Withdraw metoprolol several days before gradual clonidine withdrawal.
Mechanism
Additive negative chronotropic effect and risk of rebound hypertension
Source: NLP:metoprolol