Clarithromycin + Elexacaftor Tezacaftor And Ivacaftor Interaction

Majorinteraction on record

Description

Strong CYP3A inhibitor expected to significantly increase TRIKAFTA component exposures. TRIKAFTA dosage reduction required.

Mechanism

CYP3A inhibition

Source: NLP:elexacaftor, tezacaftor, and ivacaftor