Cimetidine + Venlafaxine Interaction
Moderateinteraction on record
Description
Cimetidine inhibits first-pass metabolism of venlafaxine, reducing oral clearance by 43% and increasing AUC and Cmax by 60%. Caution advised for patients with hypertension, elderly patients, or those with hepatic dysfunction.
Mechanism
Inhibition of first-pass metabolism
Source: NLP:venlafaxine