Cimetidine + Sitagliptin And Metformin Hydrochloride Interaction
Majorinteraction on record
Description
Reduces metformin clearance via renal tubular transport inhibition, increasing systemic metformin exposure and lactic acidosis risk.
Mechanism
Organic cationic transporter-2 (OCT2)/multidrug and toxin extrusion (MATE) inhibitor
Source: NLP:sitagliptin and metformin hydrochloride