Cimetidine + Pioglitazole And Metformin Hydrochloride Interaction
Majorinteraction on record
Description
Reduces metformin clearance, increasing systemic exposure and risk for lactic acidosis. Consider benefits and risks of concomitant use.
Mechanism
Inhibits renal tubular transport of metformin (OCT2/MATE)
Source: NLP:pioglitazone hydrochloride and metformin hydrochloride