Cimetidine + Nimodipine Interaction

Moderateinteraction on record

Description

Moderate CYP3A4 inhibitor that increases nimodipine plasma concentration. A study showed 50% increase in peak concentrations and 90% increase in area under curve. Blood pressure monitoring and dose reduction may be necessary.

Mechanism

CYP3A4 inhibition decreases first-pass metabolism of nimodipine

Source: NLP:nimodipine