Cimetidine + Fluconazole Interaction

Moderateinteraction on record

Description

Cimetidine 400 mg decreased fluconazole AUC by 13% and Cmax by 19%. Intravenous cimetidine 600-900 mg had no effect on fluconazole bioavailability.

Mechanism

Possible inhibition of fluconazole absorption

Source: NLP:fluconazole