Ceftazidime Avibactam + Probenecid Interaction
Moderateinteraction on record
Description
Probenecid inhibits OAT-mediated uptake of avibactam by 56-70% in vitro, potentially decreasing avibactam elimination. Co-administration is not recommended due to lack of clinical data.
Mechanism
Inhibition of OAT1 and OAT3 transporters, reducing avibactam renal excretion
Source: NLP:ceftazidime, avibactam