Cefotaxime + Probenecid Interaction
Moderateinteraction on record
Description
Probenecid decreases renal tubular transfer of cefotaxime, reducing total clearance by approximately 50% and increasing plasma concentrations by approximately 80%. Avoid cefotaxime doses exceeding 6 grams/day in patients receiving probenecid.
Mechanism
Interference with renal tubular transfer of cefotaxime
Source: NLP:cefotaxime