Carbamazepine + Valproate Sodium Interaction
Moderateinteraction on record
Description
Carbamazepine is an enzyme-inducing drug that can increase valproate clearance and may double it. Monitoring of valproate and carbamazepine concentrations and dosage adjustment are indicated.
Mechanism
Hepatic enzyme induction increasing glucuronosyltransferase activity
Source: NLP:valproate sodium