Carbamazepine + Methadone Hydrochloride Interaction
Majorinteraction on record
Description
CYP3A4 and CYP2C19 inducer that decreases methadone plasma concentration, reducing efficacy and causing withdrawal symptoms, with risk of serious respiratory depression and death upon discontinuation.
Mechanism
Induction of CYP3A4 and CYP2C19-mediated methadone N-demethylation
Source: NLP:methadone hydrochloride