Canagliflozin And Metformin Hydrochloride + Cimetidine Interaction

Moderateinteraction on record

Description

OCT2/MATE inhibitor that reduces metformin clearance and may increase risk for lactic acidosis. Consider benefits and risks of concomitant use.

Mechanism

Interferes with renal tubular transport of metformin, increasing systemic exposure

Source: NLP:canagliflozin and metformin hydrochloride