Butalbital Aspirin Caffeine And Codeine Phosphate + Phenytoin Interaction
Majorinteraction on record
Description
CYP3A4 inducer decreases codeine levels and morphine formation, resulting in decreased efficacy or withdrawal syndrome. Upon discontinuation, may cause serious respiratory depression.
Mechanism
Induction of CYP3A4 decreases codeine metabolism via CYP2D6 to morphine
Source: NLP:butalbital, aspirin, caffeine and codeine phosphate