Butalbital Aspirin Caffeine And Codeine Phosphate + Erythromycin Interaction
Majorinteraction on record
Description
CYP3A4 inhibitor may increase codeine plasma concentrations and morphine levels, potentially causing fatal respiratory depression, particularly when added after stable dosing.
Mechanism
Inhibition of CYP3A4 leads to increased codeine metabolism by CYP2D6, resulting in greater morphine levels
Source: NLP:butalbital, aspirin, cafeine, and codeine phosphate