Butalbital Acetaminophen Caffeine And Codeine Phosphate + Phenytoin Interaction
Majorinteraction on record
Description
CYP3A4 inducer decreases codeine levels and morphine formation, reducing efficacy or causing withdrawal. Discontinuation may increase morphine levels and cause respiratory depression.
Mechanism
Induction of CYP3A4 reduces codeine metabolism via CYP2D6 to morphine
Source: NLP:butalbital, acetaminophen, caffeine, and codeine phosphate