Buspirone + Nefazodone Hydrochloride Interaction
Majorinteraction on record
Description
Marked increases in buspirone plasma concentrations (up to 20-fold in Cmax, 50-fold in AUC) with significant decreases in metabolite. Subjects experienced lightheadedness, asthenia, dizziness, somnolence.
Mechanism
Inhibition of buspirone metabolism
Source: NLP:nefazodone hydrochloride