Buspirone + Diltiazem Hydrochloride Interaction
Majorinteraction on record
Description
Diltiazem significantly increases buspirone AUC 5.5-fold and Cmax 4.1-fold, potentially enhancing effects and increasing toxicity; dose adjustments may be necessary.
Mechanism
CYP3A4 inhibition reducing buspirone metabolism
Source: NLP:diltiazem hydrochloride