Bupropion Hydrochloride + Cimetidine Interaction
Moderateinteraction on record
Description
Cimetidine increased AUC and Cmax of threohydrobupropion and erythrohydrobupropion metabolites by 16% and 32%, respectively, but did not affect bupropion and hydroxybupropion pharmacokinetics.
Mechanism
Inhibition of bupropion metabolite metabolism
Source: NLP:bupropion hydrochloride