Azathioprine + Febuxostat Tablets 40 Mg Interaction
Contraindicatedinteraction on record
Description
Febuxostat is contraindicated with azathioprine. Concomitant use increases plasma concentrations of 6-mercaptopurine metabolite, resulting in severe toxicity.
Mechanism
Febuxostat inhibits xanthine oxidase, the enzyme that metabolizes azathioprine
Source: NLP:febuxostat tablets 40 mg