Amitriptyline Hydrochloride + Fluoxetine Interaction
Majorinteraction on record
Description
Fluoxetine inhibits P450 2D6 and may increase amitriptyline levels; caution advised with coadministration. Allow at least 5 weeks after fluoxetine discontinuation before initiating amitriptyline.
Mechanism
Inhibition of cytochrome P450 2D6
Source: NLP:amitriptyline hydrochloride