Amitriptyline Hydrochloride + Cimetidine Interaction
Majorinteraction on record
Description
Cimetidine inhibits cytochrome P450 2D6, potentially causing toxic amitriptyline levels in normal metabolizers; may require lower amitriptyline doses.
Mechanism
Inhibition of cytochrome P450 2D6
Source: NLP:amitriptyline hydrochloride