Amitriptyline + Tramadol Hydrochloride Interaction
Majorinteraction on record
Description
CYP2D6 inhibitor that increases tramadol concentrations and decreases M1 concentrations, increasing risk for serious adverse events including seizures and serotonin syndrome.
Mechanism
Inhibition of CYP2D6-mediated metabolism of tramadol to M1
Source: NLP:tramadol hydrochloride