Alogliptin And Metformin Hydrochloride + Cimetidine Interaction
Majorinteraction on record
Description
May increase metformin accumulation and risk of lactic acidosis by reducing metformin clearance through OCT2/MATE inhibition.
Mechanism
Inhibition of renal tubular transport systems (OCT2/MATE) involved in metformin elimination
Source: NLP:alogliptin and metformin hydrochloride