Ado Trastuzumab Emtansine + Nefazodone Interaction
Majorinteraction on record
Description
Strong CYP3A4 inhibitor that may increase DM1 exposure and toxicity. Concomitant use should be avoided or KADCYLA treatment delayed.
Mechanism
Inhibition of CYP3A4-mediated metabolism of DM1
Source: NLP:ado-trastuzumab emtansine